Niall Murphy, 19 and from Newry, and Joan Connor, 67 and from Drogheda, Co Louth, died after CHAR(13) + CHAR(10)a blue Ford Fiesta and a brown Nissan Qashqai collided on Dublin Road on at 5.25pm.Mr Murphy was the driver of the Fiesta while Mrs Connor (nee Holly) was a passenger of the Nissan Qashqai.The teenager is understood to have died at the scene. Mrs Connor was taken to a nearby hospital, where she died as a result of her injuries.The road was closed for a time, but has since re-opened.Police have appealed for anyone who witnessed the collision to contact them.Sinn Féin Mayor of Newry & Mourne Dáire Hughes extended sympathies to the families."The news of further fatalities on our roads has shocked and saddened the entire community and, on their behalf, I extend deepest sympathies to the families of those tragically killed," he said.Five people have died since Friday as a result of crashes on Northern Ireland's roads.A man died in hospital on Friday as a result of injuries received in a crash in Loughgall, Co Armagh earlier in the week. While on the same day, in Cullybackey, Co Antrim, two soldiers died after the car they were travelling collided with a tractor.Forty-eight people have died on the region's roads this year so far.PSNI's Road Policing Team, Assistant Chief Constable Stephen Martin described the devastation a road death brings to families, friends and local communities as "immeasurable.""Our thoughts are with all those who have been affected by these tragic events both in Northern Ireland and further afield."ACC Martin continued: "This sharp spike has again brought into focus the real need for all road users to take responsibility for their actions."The primary objective for everyone who uses our roads is to keep themselves, and others safe. Every single road user has a choice to make when they take control of a vehicle."How they exercise those choices can unfortunately sometimes mean the difference between life or death."If you choose to speed, take drink and drugs then drive, fail to wear your seatbelt, drive carelessly or dangerously you run the real risk of causing harm to yourself and others."