Mr Cameron officially opened the new wing of the company's manufacturing and assembly facility in Belfast.
The aircraft manufacturer has invested £520m and created almost 1,000 jobs over recent years as part of its expansion in the region.
Their additional facility will focus on the design, manufacture and assembly of the wings for its new C Series commercial aircraft and the new roles will be created over the next 12 months in aircraft programmes and component repair.
"Bombardier's major investment in the CSeries aircraft programme continues to bring significant benefits to the 200 companies in our UK supply chain as well as to the Northern Ireland and wider UK economies," said Michael Ryan, Vice-President and General Manager, Bombardier Aerospace, Belfast.
The jobs boost comes after an announcement on Thursday that a £120m research and development project at the company, which could create up to 230 roles, had been approved.
The Prime Minister hailed the firm's commitment as the biggest single investment in Northern Ireland.
He was speaking following his speech at Titanic Belfast, as part of a two-day investment conference, in which the PM gave a "sales pitch" for NI.
He said that the region is now second to London as the top UK destination for inward investment, with almost 8,000 jobs created from foreign investment in the last three years.
"I make no apology for being a bit of a salesman today," Mr Cameron said.
"I know some people think it's a bit undignified for a Prime Minister to make a sales pitch. But I am saying that's nonsense.
"I am passionate about the power of business to create jobs and growth.
"And I am passionate about what Northern Ireland has to offer."
I'm here today with one simple message - put your money in Northern Ireland and be part of this incredible success story.
Prime Minister David Cameron
Mr Cameron told the hundreds of delegates at the conference said he was inspired by the political process here.
"To make new investments, you want to know that the political progress we have seen in Northern Ireland will remain on track," he told the conference.
"It is a remarkable story that politicians who were adversaries are now working together.
"And I can say this as Prime Minister, having worked with Peter (Robinson) and Martin (McGuinness), the First and deputy First ministers of Northern Ireland, over these past three years, no one should doubt how serious these politicians are about working together."
"To anyone who asks whether this can endure - there is a track record in Northern Ireland of more than 15 years of progress.
"Of course, there are big political issues that still need to be resolved.
"It's simply not possible to agree on everything. But we're committed to working closely with you as you tackle these issues.
"And I know that you are determined to find lasting solutions in the interests of the whole community."
Speaking at the conference, First Minister Peter Robinson said developing the region's economy was a key priority.
"The Northern Ireland Executive's programme for government has at its heart, one priority front and centre, the creation of a vibrant economy," he said.
"Because without a strong economy, you can't tackle deprivation, you cannot deliver the health and social care that people need, you can't properly protect the environment, quality of life and you cannot deliver social change."
Deputy First Minister Martin McGuinness assured investors that Northern Ireland is a safe place to do business.
"Many of our local business are global leaders in their field," he said.
"These companies have taken our local expertise to the world stage and found international success."
As the second day of the investment conference got underway on Friday morning, police in Londonderry were dealing with a mortar attack at their Strand Road PSNI station.
Throughout the week there has also been numerous security alerts in Belfast.