The rapper, who agreed to fill-in for Drake after the ill Canadian announced he wouldn't be able to perform on Saturday, had a less than smooth experience on the opening night of the Finsbury Park event as music fans took exception to his ranting onstage.
Kanye was booed and heckled by festival-goers as he took aim at the media during a break in his set.
He told the crowd: "I'm not particularly angry but they've taken the idea of celebrity and tried to make me seem like I'm stupid or something. People keep looking at me like I got a problem or something, like I'm not doing something I'm meant to. The lies, the media, they want to make you feel like you're less to them in their eye."
Kanye also attacked top fashion brands such as Nike and Louis Vuitton, who he has fallen out with in the past - but it appeared fans weren't in the mood for a soapbox performance and they started leaving the venue in waves.
Tinie Tempah, Iggy Azalea, Pharrell Williams and Basement Jaxx also performed at Wireless on Friday, while Bruno Mars, Robin Thicke, Salt-N-Pepa and Ellie Goulding are among the other acts playing over the weekend.