Published Friday, 13 June 2014
Robin van Persie celebrates with head coach Louis van Gaal after scoring (© Getty)
Robin van Persie and Arjen Robben inspired Holland to avenge their defeat by the Spaniards in the 2010 final.
Van Persie and Robben scored two apiece, while defender Stefan de Vrij scored his side's third - with four Dutch goals left unanswered in the second half.
Vincent Del Bosque's side, who also lost their opener against Switzerland four years ago, had taken the lead through Xabi Alonso's disputed penalty.
But Van Persie's flying header levelled matters just before the break.
Holland took the lead eight minutes into the second half, through Robben.
De Vrij made it 3-1 after the hour, after Iker Casillas came to claim a free-kick but failed.
Van Persie and Robben then both beat Casillas to complete Spain's misery.
Earlier Van Persie celebrated his first goal with his new Manchester United manager Louis van Gaal with a high five on the touchline.
Del Bosque now wants to see a big response when the Spaniards face Chile in their second Group clash.
"It's sport, we lost. It is necessary to accept defeat," he said.
"We must recognize our mistakes, but everyone fought for a better result."
© UTV News