Ulster forwards Dan Tuohy and Declan Fitzpatrick have been rewarded for their excellent club form by being named in the Ireland squad for the 2010 RBS Six Nations Championship.
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They are two of nine uncapped players named by Ireland Coach Declan Kidney.
Tuohy has been in commanding form for the Ravenhill side, particularly impressing in the Heineken Cup wins over Stade Francais and Edinburgh. Fitzpatrick has only started two games for the province this season.
Ulster hooker Rory Best is also included in the 44 man panel after recovering from a neck injury earlier than expected.
He underwent surgery last summer, but has recently returned to contact training.
Munster prop Horan returns having missed out on the autumn internationals after undergoing a routine medical procedure for a minor heart ailment.
Reigning Grand Slam Champions Ireland open the Championship against Italy in Croke Park on Saturday 6 February.
But Kidney admitted his selection was made with one eye on developing his squad ahead of the 2011 World Cup.
"Building a squad has always been a priority for us and the work done during the first half of the season means there is a little more experience accumulated in the squad then we had a couple of months ago," he said.
"While there were new players who gained vital experience during the Guinness Series, the goal is to keep that experience ticking over with all the players who need international level game time.
"The focus is very much on our game against Italy in a fortnight's time and we are preparing for that first challenge".
Ireland Squad (44):
Rory Best (Belfast Harlequins/Ulster)
Isaac Boss (Ballymena/Ulster)
Tommy Bowe (Ospreys)
Tony Buckley (Shannon/Munster)
Tom Court (Malone/Ulster)
Sean Cronin (Buccaneers/Connacht)
Leo Cullen (Blackrock College/Leinster)
Gordon D'Arcy (Lansdowne/Leinster)
Ian Dowling (Shannon/Munster)
Keith Earls (Young Munster/Munster)
Stephen Ferris (Dungannon/Ulster)
Declan Fitzpatrick (Belfast Harlequins/Ulster)*
Jerry Flannery (Shannon/Munster)
John Fogarty (De La Salle Palmerston/Leinster)*
John Hayes (Bruff/Munster)
Cian Healy (Clontarf/Leinster)
Jamie Heaslip (Naas/Leinster)
Chris Henry (Ballymena/Ulster)*
Marcus Horan (Shannon/Munster)
Shane Horgan (Boyne/Leinster)
Denis Hurley (Cork Constitution/Munster)
Shane Jennings (St.Mary's College/Leinster)
Robert Kearney (UCD/Leinster)
Fergus McFadden (UCD/Leinster)*
Kevin McLaughlin (UCD/Leinster)*
Johne Murphy (Leicester)*
Donncha O'Callaghan (Cork Constitution/Munster)
Paul O'Connell (Young Munster/Munster)
Mick O'Driscoll (Cork Constitution/Munster)
Brian O'Driscoll (UCD/Leinster)
Ronan O'Gara (Cork Constitution/Munster)
Tomas O'Leary (Dolphin/Munster)
Sean O'Brien (Clontarf/Leinster)
Eoin Reddan (Lansdowne/Leinster)
Mike Ross (Clontarf/Leinster)
Donnacha Ryan (Shannon/Munster)
Jonathan Sexton (St.Mary's College/Leinster)
Peter Stringer (Shannon/Munster)
Devin Toner (Lansdowne/Leinster)*
Andrew Trimble (Ballymena/Ulster)
Dan Touhy (Ballymena/Ulster)*
David Wallace (Garryowen/Munster)
Paddy Wallace (Ballymena/Ulster)
Brett Wilkinson (Galwegians/Connacht)*
© UTV News