Paddy Jackson and Darren Cave are named in the backline, while Iain Henderson, Rob Herring, Declan Fitzpatrick, Lewis Stevenson and Mike McComish return to the pack.
Anscombe has also made three positional changes, the most notable of which sees captain John Afoa switch from tight-head to loose-head prop.
It will be the first time that Afoa has started for Ulster at loose-head.
Andrew Trimble moves from outside centre to his more familiar position on the right wing, while Michael Allen switches flanks and will start at number 11.
15-9: R Andrew, A Trimble, D Cave, S Olding, M Allen, P Jackson, R Pienaar.
1-8: J Afoa, R Herring, D Fitzpatrick, L Stevenson, D Tuohy, I Henderson, M McComish, R Diack.
Replacements: N Brady, C Black, R Lutton, N McComb, A Birch, P Marshall, N O'Connor, C Cochrane.