Published Tuesday, 10 September 2013
NI players in training ahead of the match. (© Presseye)
The reverse fixture finished in a 1-1 draw at Windsor Park last September after the hosts failed to take their chances.
Following the disappointment of the 4-2 defeat to Portugal - in which Michael O'Neill's men had led only to see two red cards and a Christiano Ronaldo hat-trick spoil the party - the NI manager believes Tuesday night's game at Stade Josy Barthel will be an important test.
"We've said to the players that Portugal was our bonus ball," explained O'Neill. "To be honest, the three points we really needed was in this game.
"The Portugal game was fantastic in terms of positives, and it was hugely disappointing from a winning position to lose the game, but if I'd been given the choice of taking four points I would have rather drawn with Portugal and beaten Luxembourg than the other way around.
It is imperative that we take points
"They come into this game with everything to gain. It's similar to us when we go and play Russia and Portugal - they will look at players like Steven Davis and Jonny Evans playing in the Premier League as a big thing."
Northern Ireland will have to overcome a player shortage following last week's game in which Chris Brunt and Kyle Lafferty were sent off, with Dean Shiels called up as cover.
O'Neill said he has spoken with Lafferty about his performance.
"The reality is that he misses this game suspended and I'd say he'll miss the next two as well, that wouldn't surprise me," said O'Neill.
"We will address it after that. I had a good conversation with Kyle and was very apologetic and recognises he has let his team-mates down.
"I would never say I would wash my hands of him or anything like that because he is still a player who can potentially be a big asset to the squad.
"But at this minute in time he is not giving us very much and he knows that.
"After quite a good start to the campaign he has contributed very little and he knows he won't have contributed very much in the second half of the campaign."
Northern Ireland have a history of giving their best performances against some of Europe's top sides but have in turn struggled to get results against the relative minnows.
O'Neill is hoping to put the record straight in Luxembourg.
He continued: "It's a big occasion for their players so they will think it's nice to take a big scalp and play against players at this level and come away with a result."
© UTV News