Published Saturday, 13 October 2012
Grant McCann, seen in actiona against Estonia, has a knee injury. (© Pacemaker)
Hull defender Bruce is suffering from a groin strain while Peterborough midfielder McCann has a knee problem.
Bruce, 28, was in line to make his competitive debut for Northern Ireland after switching his allegiance from the Republic.
No replacements for the pair have been called up.
The latest withdrawals bring the total number of players to have pulled out of the squad to six.
Bruce's club mate Joe Dudgeon, who was also in line to make his international debut, pulled out earlier in the week along with Shane Ferguson, Martin Paterson and James McPake.
Chris Brunt and Jamie Ward were not considered for the squad due to existing injuries, while goalkeeper Lee Camp is unavailable for personal reasons.