Linfield welcome Cliftonville to Windsor Park on a Tuesday night of County Antrim Shield action.
However Cliftonville are up against it before a ball has even been kicked due to injury problems.
Eddie Patterson is without Ryan Catney and Mark Holland for the trip to the Blues.
There are also serious concerns over George McMullan, Barry Holland and Stephen Garrett.
Lisburn Distillery journey to the Oval and hope to wipe out the bitter memories of an opening-day 6-1 defeat to Glentoran.
Glens boss Scott Young has insisted he will field his strongest possible line up for the match.
The other tie sees Ballymena United welcome Shield holders Crusaders to the Showgrounds.
Ballymena were beaten by a late goal last week in the League by Stephen Baxter's men and the Crues dumped United out of this tournament en route to winning it last season.
In the night's other tie Donegal Celtic welcome Amateur League side Kilmore Rec.
All the games kick-off at 7.30pm.
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