Jamie Heaslip remains captain of Declan Kidney's squad, while Ulster's Craig Gilroy and Rory Best are both on the line up.
Gordon D'Arcy and Peter O'Mahony have been named fit after they suffered a dead leg and concussion respectively during last weekend's victory over Wales.
Declan Fitzpatrick and Chris Henry are among the replacements for the match which takes place at the Aviva Stadium.
Keith Earls will sit alongside them on the bench after recovering from a damaged shoulder against Wales.
"The players have recovered pretty well from the Wales game. We took 48 hours off after the match and have toned down training since," said head coach Declan Kidney.
"Gordon, Peter and Sean all trained fully this morning so we don't envisage there being any changes."
It will be Ireland's second match in this year's Six Nations competition after defeating Wales 30-22 at Cardiff on Saturday.
The home side destroyed England's chance of a grand slam in 2011 when they defeated the visitors 24-8 in Dublin.
But England have not beaten Ireland in Dublin during the Six Nations for almost ten years and with seven wins in nine championship meetings, Ireland should be tipped to come out on top. However, bookers are unable to split them with both teams valued at 10/11.
Rob Kearney, Craig Gilroy, Brian O'Driscoll, Gordon D'Arcy, Simon Zebo, Jonathan Sexton, Conor Murray, Cian Healy, Rory Best, Mike Ross, Mike McCarthy, Donnacha Ryan, Peter O'Mahony, Sean O'Brien, Jamie Heaslip.
Sean Cronin, David Kilcoyne, Declan Fitzpatrick, Donncha O'Callaghan, Chris Henry, Eoin Reddan, Ronan O'Gara, Keith Earls.