Published Tuesday, 10 April 2012
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The boat left the docks on the south coast of England at midday on 10 April 1912.
Events have been held in the city in Tuesday to mark the centenary of Titanic's departure, six days after it arrived from Belfast where it was built.
A service of remembrance was held at the dockside in memory of the 549 people from Southampton who died when the ship sank after hitting an iceberg in the Atlantic Ocean.
During the ceremony a minute's silence was held in honour of all 1,514 passengers who lost their lives, followed by a sounding of the ship's whistle as descendants threw flowers on the dock.
More than 600 schoolchildren carried placards remembering the dead on a parade through Southampton city centre, ending at a new museum which includes a Titanic exhibition.
It comes as events marking significant milestones in the manufacture, voyage and sinking of the famous steamship continue to take place in several countries.
A cruise liner which is retracing the route the Titanic took departed from Southampton over the weekend before stopping in Cobh, Co Cork - Titanic's last port of call.
Hundreds of people turned out in the Republic of Ireland to see the MS Balmoral on Monday.
Some of the passengers on board the ship are descendants of those who died - they will stop at the exact moment and exact spot the steamship went down on 15 April.
Meanwhile events in Northern Ireland started earlier this month with the opening of the £97m Titanic Belfast visitor centre, while the Titanic Festival will run to 22 April.