June will see a host of world leaders attend the 39th summit at the Lough Erne golf resort - the first time the G8 has been held in the UK since it was the turn of Gleneagles in Scotland back in 2005.
"As leaders of eight countries making up around half of the world's entire GDP, the ambitious standards we set and the bold steps we take by working together through the G8 can make a tangible difference by firing up economies and driving prosperity, not just in our own countries, but all over the world," Mr Cameron said.
"I hope that at Lough Erne we can seize this opportunity."
According to the Prime Minister, three issues will be at the heart of the forthcoming event - namely advancing trade, ensuring tax compliance and promoting greater transparency.
This G8 will not be the kind of Summit where we simply whip out a chequebook at the 11th hour, pledge some money and call it a success.
PM David Cameron
"All of them are areas where I believe the G8 can play a distinctive role, using our commitment to open economies, open governments and open societies to support enterprise and deliver economic growth," Mr Cameron said.
"But to achieve this will require strong political leadership and months of detailed policy work from our teams.
"What we are talking about are long-term changes in our countries and the rules that govern the relationships between them."
US President Barack Obama, Russian President Vladimir Putin and German Chancellor Angela Merkel will be among the leaders attending the summit in Fermanagh, which - it is hoped - will also provide a chance to showcase Northern Ireland on a global scale.