Published Monday, 26 August 2013
Martin Luther King delivers his iconic 'I have a dream' speech in August 1963. (© Getty)
Mr Hume, known for his civil rights work, has previously been awarded the Gandhi Peace Prize and the Martin Luther King Award - the only person to have received all three major peace awards.
The former SDLP leader will join other figures like the Dalai Lama and Doreen Lawrence - whose son Stephen was murdered in a racist attack - in taking part in the broadcast.
Nelson Mandela's granddaughter Ndileka and Malala Yousafzai, the 16-year-old Pakistani girl shot by the Taliban for going to school, will also be featured.
I have a dream that my four little children will one day live in a nation where they will not be judged by the colour of their skin, but by the content of their character.
Martin Luther King
Recordings of Martin Luther King's original speech will be mixed with excerpts spoken by the guests for a broadcast on BBC Radio 4 and the World Service.
"I am happy to join with you today in what will go down in history as the greatest demonstration for freedom in the history of our nation," Doctor King said back on 28 August 1963.
He was speaking during a civil rights rally in Washington DC.
"Now is the time to make real the promises of democracy," he said.
"Now is the time to rise from the dark and desolate valley of segregation to the sunlit path of racial justice. Now is the time to lift our nation from the quick sands of racial injustice to the solid rock of brotherhood.
"Now is the time to make justice a reality for all of God's children."
When we allow freedom to ring ... we will be able to speed up that day when all of God's children - black men and white men, Jews and Gentiles, Protestants and Catholics - will be able to join hands and sing: 'Free at last! Free at last! Thank God Almighty, we are free at last!'
Martin Luther King
Radio 4 controller Gwyneth Williams said: "Martin Luther King's words constitute one of the most passionate political statements of the 20th century - a source of inspiration in the quest for freedom in so many different countries around the world.
"I am delighted that Radio 4 is able to bring the whole speech to a global audience for the first time since 1963.
"I'm also thrilled that we have managed to gather such a distinguished host of contributors to mark the 50th anniversary."
The broadcast will air at 9am on Wednesday and then at 2.30pm on the World Service.
© UTV News