Joanna Craig's family had reported her missing after she failed to return home on Tuesday.
She was last seen at around tea time on Tuesday in the Castlereagh Road area, where she lives with her husband Gary and their children.
The 28-year-old had left home in the family car, but failed to return.
On Thursday morning, Mr Craig said: "She had arranged for one of her sisters to babysit and she had gone out in the car and we have not heard from her since.
"There has been no contact with her on her phone. We've been trying constantly and her phone is now dead."
Police tracked Mrs Craig's phone to the Lower Ormeau Road - but her husband said she did not know anyone who lives in that area, and believed she could have been at a B&B or a hotel in the university area.
PSNI also searched by helicopter for Joanna, and Mr Craig said friends and family had also been trying to track her down.
"She's not the kind of person who would behave in this way and because she is the person she is, the police are very concerned that she's disappeared in this fashion."
Her husband explained the couple recently lost their business and that he had been ill in hospital, but it was his wife who kept the family together.
"We've had a very stressful year," he added, before saying the disappearance was very out of character.
Mr Craig began to break down as he made an appeal on the Frank Mitchell's show on U105, calling for his wife to make contact.
He said: "I'm hoping that maybe Joanna's listening to the show and if she is she knows how much we love her, and how much we treasure her.
"She loves the kids. She's a great mother and we need her back.
"We are so worried about her, we desperately need to hear from her to know that she's ok," he added.
Police said Joanna had been located on Thursday afternoon.
"The PSNI would like to thank all media outlets who assisted in appealing for Joanna," the spokesman added.