Social Development Minister Nelson McCausland announced a £233,000 funding boost for the project on Monday.
He said it will go towards a painting and signage scheme aimed at making the Co Fermanagh town "brighter and more vibrant" in the hope of attracting shoppers.
It will also be used to deliver marketing training for store owners.
With eight of the world's most powerful leaders coming for the two-day conference this June, Mr McCausland said the eyes of the world will be on Northern Ireland.
"In these difficult trading times it is essential that town centres appear as attractive and welcoming as possible," the DUP minister said.
"In June, the eyes of the world will be on Enniskillen and this project will strengthen the physical retail core of the town by improving its appearance.
"This project will ensure the reinvigoration of Enniskillen town centre. It will enable businesses and property owners within the town centre to make improvements which will create a brighter and more vibrant streetscape to attract shoppers and visitors."
The grant has been made to Fermanagh District Council who will appoint a Creative Management Team to prepare a design guide and manage the delivery of the project.
Tourism Minister Arlene Foster said: "The NI Tourist Board is helping to ensure that everyone coming to the region for the G8 receives a warm Northern Ireland welcome.
"We are working closely with Fermanagh Lakeland Tourism, Fermanagh District Council and other G8 partners to develop opportunities to ensure that visitors not only get an authentic taste of NI during their stay, but that they are also encouraged to stay for longer."