Pauline Haveron, a part-time nurse, was found dead and floating face down in the bath at her Huntingdale Green home in Ballyclare by her younger partner.
Her 58-year-old ex-husband, Joseph Alfred Haveron, from Farmlodge Grove, Greenisland, was due to have gone on trial again at Armagh Crown Court on Tuesday. This was after a new jury was supposed to have been selected in Newry the previous day for the retrial.
However, prosecuting QC Liam McCollum, told Mr Justice Treacy that following a full review of the evidence, the prosecution did not intend to proceed with the second trial.
Last month, during Haveron's Belfast Crown Court trial, the jury was dismissed after the same judge questioned expert forensic evidence called on behalf of the prosecution.
Mr Haveron has endured the nightmare of investigation and prosecution for this terrible, terrible act.
On Tuesday, Mr McCollum said having reviewed that evidence they were no longer relying upon it as it did not "meet the test for prosecution".
A new jury of six men and six women was sworn in on Tuesday morning and received a direction from the judge to find Mr Haveron not guilty.
Outside the court, Mr Haveron's solicitor, John Burke, said his client is looking forward to moving on with his life.
"The sense of relief that he feels at his vindication is tempered by the great sadness he feels for his children, who have lost a wonderful and caring mother, and the Howard family who have lost a devoted daughter and sister," he added.