Published Friday, 18 July 2014
The activity of the two genes, called MEK and MET, was uncovered when the researchers looked at all the different pathways and interactions taking place in bowel cancer cells.
Dr Sandra van Schaeybroeck and her team at Queen's University, Belfast found that these bowel cancers adapt a survival mechanism when they are treated with drugs that target faulty MEK genes.
But when the researchers added drugs that also block the MET gene, the bowel cancer cells died.
The team are now testing a new approach to target these two genes in the most aggressive forms of bowel cancer in a European Commission funded clinical trial that is being led by Dr van Schaeybroeck.
The clinical trial is called MErCuRIC and is due to start in September.
It will deliver personalised medicine to Northern Irish patients and patients from other European countries.
The Europe wide effort will involving 13 research/clinical teams from nine countries.
At present, over 40,000 people are diagnosed with bowel cancer in the UK each year and over 16,000 patients die as a result of the disease.
More than half of patients develop the aggressive form of the disease which does not respond to standard therapy. The five year overall survival period in this patient group is less than five per cent.
Dr Sandra van Schaeybroeck, from the Centre for Cancer Research and Cell Biology (CCRCB) at Queen's, said: "We have discovered how two key genes contribute to aggressive bowel cancer. Understanding how they are involved in development of the disease has also primed the development of a potential new treatment approach for this disease."
Queen's University Vice-Chancellor, Professor Patrick Johnston, added: "Understanding the genes that cause bowel cancer is a key focus of our research. Our discoveries in this deadly disease have identified a new route to clinical application for cancer patients."
Professor David Waugh, Director of the CCRCB at Queen's, said: "The publication of this research by Dr van Schaeybroeck and her team demonstrates our commitment to performing excellent science here in Belfast that can be directly translated to the clinic."
The significant breakthrough, which was funded by Cancer Research UK, was published this month in the prestigious international journal Cell Reports.
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