The branches scheduled for closure are Ballyclare, Ballymoney, Carrickfergus and Larne, all in Co Antrim; Kilkeel and Rathfriland in Co Down; and Kilrea in Co Londonderry.
Meanwhile, the city of Derry's Shipquay Street and Waterside branches will shut to merge with the bank's main commercial hub at Strand Road.
The closures will take place between May and June, reducing the number of branches in the region from 44 to 35.
Staff affected will be either redeployed to suitable roles in other branches or businesses, or become potentially eligible for existing redundancy programmes, a statement released on Wednesday confirmed.
The bank said it will be writing to all affected customers detailing the changes that are taking place.
Bank of Ireland is investing £10million in its branch network, upgrading and modernising the remaining outlets, the statement added.
Sean Sheehan, Regional Manager NI, said: "To help deliver our strategy for Northern Ireland we are investing in a modern branch network that provides customers with easy access to banking services and is fully integrated with our online, phone and mobile channels.
"As part of that investment, we have already opened a new branch, City Hall Branch in Belfast city centre, and upgraded nine branches," he said.
"We also have to ensure that the network is cost-effective and fit for purpose. We understand that closing branches is disappointing for those who use them but the volume of business at the branches involved means they are not sustainable in the long term. We will continue to service those customers through larger branches which are being modernised and upgraded."