Up to 120 jobs are under threat at Halifax in Belfast.
It is understood that the redundancies will affect the Mortgage Operations team at Cromac Square.
A spokesman for the bank told UTV that the work is being transferred to other sites in the group in October 2010.
He added that some workers would be redeployed where possible.
"We anticipate 120 roles to be affected. However, it's important to remember that we retain a significant presence in the region and will always look to redeploy potentially impacted colleagues.
"As always our preference is to manage role reductions through natural turnover, redeployment and voluntary redundancy," he said.
Halifax is a brand name of Bank of Scotland, a subsidiary of the Lloyds Banking Group.
Lloyds has confirmed that around 5,000 jobs would be hit by changes within its group operations, insurance and retail divisions by the end of 2010.
The bank said the cuts would be "significantly mitigated" by redeployment and the release of contractors, temporary staff and offshore employees.
"Taking these mitigating actions into account means there will be a net reduction of about 2,600 permanent jobs across the UK by the end of 2010," the bank said in a statement.
Several thousand jobs have been cut this year, leaving Lloyds with around 130,000 employees.
Mark Fisher, group integration director, Lloyds Banking Group, said: "Today marks another important step in bringing our businesses together. .
"We will continue to work closely with our colleagues affected by today's announcement to help them through these changes over the coming year."
Rob McGregor, national officer of the Unite union, said: "This Lloyds Banking Group announcement of 5,000 job losses demonstrates the depth of corporate arrogance within this taxpayer-supported bank.
"This country's financial sector should be looking towards the future, rather than continuing to slash jobs without proper consideration of how to rebuild the public's confidence in our tarnished banking sector."
Lloyds has cut around 10,000 jobs since taking over HBOS at the end of last year.
© UTV News