The REMember fundraiser, which took place at The Limelight in December, paid homage to American rock band R.E.M and also included local bands Amidships, The Jane Bradfords, Katie & The Carnival and Runaway GO.
Snow Patrol's singer Gary Lightbody, guitarist Nathan Connolly and keyboardist Johnny McDaid opened their set with a rendition of R.E.M.'s Nightswimming, before treating the 800-strong crowd to some of their chart hits.
As well as proceeds from ticket sales, money for the charity was raised by raffling off a signed Snow Patrol set-list, which sold for over £1,000.
The event was organised by local DJ Joe Lindsay, in honour of a close family member who has Alzheimer's disease.
He said: "A relative of mine has Alzheimer's and was diagnosed seven years ago. It's a devastating disease that directly or indirectly affects everyone I know, yet research into Alzheimer's disease and other dementias is so drastically underfunded.
"I've wanted to put on a gig to raise money for research for a while and chose the R.E.M. theme as I'm a massive fan and the group had such an influence on so many acts, including many of the groups which performed on the night.
"As a country we love to raise money through music and it's something we do well. We have a great music community in Belfast and the atmosphere on the night was incredible.
"It was a big ask for Snow Patrol to headline the night as they're rarely at home at the same time. I've known the boys for years and they didn't hesitate when I asked if they'd perform at the event. They're just a great bunch of lads who happen to be amazingly talented and successful.
Jodie Vaughan, Community Fundraising Manager at Alzheimer's Research UK, said: "We are absolutely thrilled by the amount raised by Joe through his incredible concert. Although the final total is yet to be calculated, Alzheimer's Research UK can expect to receive around £10,000 from the night - enough to pay for 500 hours of world-class research.
Speaking ahead of the cheque presentation, Phil Donaldson from The Limelight said: "The REMember fundraiser was a fantastic night for the NI music scene, with great local acts coming together to raise much-needed funds for an excellent charity.
"Our thanks go to everyone that worked so hard to make this event possible."