The eight-day event, which was brought to a close with a spectacular ceremony at Ebrington Square on Sunday night, with around 9,000 people believed to be in attendance.
It was first time the world's biggest celebration of Irish culture had been held north of the border and organisers say huge numbers have made it the most successful Fleadh in its 63 year history.
Culture Company Chief Executive Shona McCarthy, congratulated Fleadh chairperson Eibhlinn ni Dochartaigh and praised the citywide effort that made the event such a success.
She also thanked Labhras O Murchu and Comhaltas for giving the city the opportunity to host the event.
"Fleadh Cheoil na hÉireann is always a special experience, but this year as it came north for the first time and was hosted by a city for the first time, and in the context of an extraordinary year for Derry-Londonderry, it has been magical," she said.
"The momentum has been building since our opening concert in January and I think we can truly begin to say that this is a city transformed, visually, physically and psychologically through this immense cultural experience.
"With only four months to go, there's a rich programme through the autumn and winter months and the city's doors are well and truly open."
The people of Derry have really taken the Fleadh to heart. It has been quite emotional to see the sense of pride people have in our city."
Fleadh chairperson Eibhlín Ní Dhochartaigh
The Fleadh, which will be next held in Sligo, was opened a week ago by Irish president Michael D Higgins - the first time any Irish president had attended.
The closing party included an aerial spectacular with musicians and dancers from Fidget Feet suspended in the air above Ebrington Square.
Fleadh chairperson Eibhlín Ní Dhochartaigh said it had been an unbelievable experience for the city.
Ms Ni Dhochartaigh added: "The Fleadh may be leaving Derry but is leaving behind a renewed appreciation of our music and culture. We have always known that Derry is a city of song but now the whole world knows it too.
"Over the last week millions of people across the world had the chance to share this wonderful experience with us through Fleadh Live and the feedback from that has been phenomenal."
The huge trad fest generated around £40m for the economy in the north west. The diverse programme of events included participation from the Police Service of Northern Ireland pipe band as well as Jonathan Burgess' play The Pride about a loyalist band.
Around 20,000 musicians descended on Derry to compete in what was described as the "Olympics of traditional music" and there also were performances from Cara Dillon, Dervish and Liam O'Flynn.
Once again Derry has demonstrated its ability to host major events, attract international names in music and culture and showcase the breadth and variety of talent that exists within the city itself.
Stephen Martin, PSNI District Commander
Speaking on Monday, PSNI District Commander Chief Superintendent Stephen Martin said police were delighted to have played a part in the event's success.
"This has been a significant and resource intensive week and not without challenge, however, I am delighted with the many compliments we have received around our friendly and reassuring policing style," he said.
"This week has allowed us to engage with a huge number of people, many of them first time visitors to the city and to Northern Ireland. I know that our Irish speaking officers attracted a lot of attention and for them it was a great opportunity to brush up on their language skills and open up yet another channel of engagement.
"The PSNI pipe band played on Thursday afternoon and went down a storm, receiving a wonderful and enthusiastic welcome. I am confident that the vast majority of people have left with positive memories of the service we provided and the welcome they received."
The final day also saw a world record attempt as thousands took part in a bid to achieve the world's longest Riverdance.
Over 2,500 people from dance schools joined in the charity event - the previous record held by a US group only had 652 participants.
Derry was a late confirmation on the shortlist for the 2013 Fleadh after the Ulster Council of Comhaltas Ceoltóirí Éireann reversed its decision not to support the bid following two bomb attacks in the city in 2011.