Published Friday, 23 September 2011
Twenty-eight venues across the region are getting in on the act, including Londonderry, Strabane and Newry.
But Belfast is leading the way with over 170 artistic events taking place as part of the capital's cultural extravaganza.
The spotlight will be on Cathedral Quarter, where a packed schedule of entertainment - everything from electronic vibes to visual arts - will be put on for visitors of all ages.
The University of Ulster will play host to the proceedings, and its Arts and Culture Development Manager, Tim Kerr, said he is looking forward to a "fabulous cocktail of activity".
"Our campus in York Street is smack bang in the middle of the Cathedral Quarter," he said.
"Culture Night is a magnificent opportunity for us to host a creative feast, as the area comes ablaze with a fabulous cocktail of activity.
"I'm sure our corridors will be alive with people, sounds and colour - it's great to be playing our part in the day's festivities."
Meanwhile in Derry, the future City of Culture in 2013, singer Peter Corry said he is looking forward to making his contribution.
"I'm doing a performance in the Guildhall Square," he told UTV.
"It's nice for people to be able to walk around the city and not to feel they have to walk into a building for a live performance but for the performance to come to them."
Another unique attraction aims to bring fashion back to the original 'catwalk' - the city walls.
Tony Monahan, from Culture Night, said it is where ladies used to go to parade up and down.
"Tonight we're hosting a fashion show on the Grand parade," he told UTV.
"It's the original catwalk, were people came parading in their finery and the ladies would walk past each other and slow down to get an eye of what each one was wearing.
"It could get quiet cat like so that's where the phrase was coined. So tonight's show will show the fashions of the early 18th century right up to present day."
Organisers are hoping the public will fancy a Friday night with a difference, and will go out and soak up the local culture right across Northern Ireland.