Published Tuesday, 01 April 2014
Frankie Knuckles, pictured in 2007. (© Getty)
Best known for his pioneering dance tracks, Knuckles' hits included Your Love and The Whistle Song.
He also remixed huge hits by Michael Jackson and Whitney Houston.
News of Knuckles' death was confirmed on Twitter by fellow DJ David Morales.
He wrote: "I am devastated to write that my dear friend Frankie Knuckles has passed away today. Can't write anymore than this at the moment. I'm sorry."
The DJ had recently performed at London's Ministry of Sound.
A statement on the musician's death is expected later on Tuesday.
© UTV News