The actress, who is engaged to Derry man and Snow Patrol guitarist Johnny McDaid, landed at the City of Derry Airport after flying in from London Stansted.
Her arrival was reported on Twitter when the airport posted a picture of the star with staff members, writing: "CoDA was delighted to welcome Courteney Cox following her Ryanair flight from (Stansted) #friends."
It is believed she is in the city to meet her fiancé's family.
The couple announced their engagement last month by posting the same picture on their Twitter accounts with the captions: "I'm engaged to him" and "I'm engaged to her".
The pair began dating last year after being introduced by a mutual friend, singer Ed Sheeran.
The reportedly moved in together in April.
This is the first marriage for McDaid and the second for Cox, who split from ex-husband, actor David Arquette, in 2010 after 11 years together.