David Neilson and Julie Hesmondhalgh - who played husband and wife Roy and Hayley Cropper - walked away with a total of six wins between them.
Hayley's cancer storyline saw the well-loved couple work through Hayley's bucket list, which included dancing at the Tower Ballroom in Blackpool, before she took her own life with Roy beside her as her illness reached its final stages.
Neilson and Hesmondhalgh were awarded Best Actor, Best Actress, Best Dramatic Performance (Neilson), Best On-Screen Partnership, Best Storyline for Hayley's cancer and Best Single Episode for Hayley's death.
Hesmondhalgh said of not working with Neilson any more: "It's like a marriage. We went out for a pint in Manchester the other week, it was lovely.
"I told him all the gossip, even though I'm not in it any more I know all the gossip and he doesn't.
Neilson explained the toll the storyline had taken on him: "My personal life was a complete write off last year because I was living Roy's life."
He added modestly of the storyline: "I'm glad we got the result but I don't do pride much."
That kind of working relationship comes once in a lifetime.
Julie Hesmondhalgh on her partnership with David Neilson
Corrie's other wins included Outstanding Achievement for Helen Worth who has played Gail McIntyre for 40 years, Best Comedy Performance for Simon Gregson who plays Steve McDonald and Sexiest Female went to Michelle Keegan for the sixth year running.
Keegan, whose character Tina McIntyre is due to be killed off this week, said of her nomination: "It's flattering. I can't believe I won in the first place a few years back."
Emmerdale managed to convert just one of their nominations into a win with Spectacular Scene for The Woolpack's flood and siege.
It was a huge night for Hollyoaks as the soap picked up the Best Soap award for the first time, while actor Danny Mac, who plays Dodger Savage in the show, held on to his crown as Sexiest Male.
The soap also got Best Villain in Anna Passey who plays Sienna Blake, and Ellis Hollins won Best Young Performance as Tom Cunningham.
EastEnders got just two awards - Best Newcomer for Maddy Hill as Nancy Carter and Outstanding Achievement Off Screen for company manager Carolyn Weinstein.
The British Soap Awards airs on UTV on Sunday at 8.15pm.
British Soap Award winners 2014:
Sexiest male: Danny Mac - Hollyoaks
Sexiest female: Michelle Keegan - Coronation Street
Villian of the year: Anna Passey - Hollyoaks
Best actor: David Neilson - Coronation Street
Best actress: Julie Hesmondhalgh - Coronation Street
Best comedy performance: Simon Gregson - Coronation Street
Best young performance: Ellis Hollins - Hollyoaks
Spectacular scene of the year: The Woolpack Flood & Siege - Emmerdale
Best on-screen partnership: David Neilson & Julie Hesmondhalgh - Coronation Street
Best newcomer: Maddy Hill - EastEnders
Best dramatic performance: David Neilson - Coronation Street
Best storyline: Hayley's cancer - Coronation Street
Best single episode: Hayley's death - Coronation Street
Outstanding achievement award: Helen Worth - Coronation Street
Outstanding achievement (off screen): Carolyn Weinstein (Company Manager - EastEnders)
Best british soap: Hollyoaks