The quirky one-act recounts the hopes - and fears - of six quirky children taking part in a spelling competition.
From over-achieving Marcy Park to Leaf Coneybear, who is struggling to make it known that he didn't actually win his regional heat, Bruiser Theatre Company showcases a lively production of the unusual musical.
Spelling Bee kicked off its popular run in New York eight years ago, and went on to claim a Tony Award, before featuring on Broadway for more than 1,000 productions.
It is a return to the MAC for Bruiser and a special occasion for the theatre as it celebrates its first birthday.
The venue's Gillian Mitchell said they were delighted to welcome the company back to the MAC.
She said: "This show opens on the week we celebrate our first birthday and is the perfect show to create a feel-good mood in the venue. Based on the success of Sweet Charity, we know that Bruiser and the MAC make a great team.
"Spelling Bee is a relatively new musical- released on Broadway in 2005 it has gone on to achieve critical acclaim and has won a Tony award. We're thrilled to bring it to Northern Ireland for the first time and hope to kick off our spring season and celebrate the MAC's first year in style."
Stephen Beggs from Bruiser Theatre Company added: "Spelling Bee is a great production to work on; it has all the credentials of being a Tony award winning show yet has the scope to put our own mark on it.
"We have an outstanding cast in the form of local actors Gerard McCabe, Fiona Carty and Terence Keeley to name but a few and really hope that the audiences enjoy this production as much as we have enjoyed making it."
There are a few surprises in store for the audience - as this show was originally based on an improvised production, and some of the characters may not be what they seem.
The show runs every day at the MAC from April 16 to May 4.