Up to two feet of snow caused significant damage and forced the zoo to close almost two weeks ago.
Since then, staff and contractors have removed numerous trees, repaired enclosures and cleared roads and pathways of snow to make the Cavehill site accessible and safe for both animals and visitors.
"We had originally aimed to re-open on Thursday 4 April but there is still some essential maintenance work outstanding around the site, including some repairs to the Sumatran tiger and African wild dog enclosures," manager Mark Challis said.
"Although this has been an extremely disappointing and difficult time for the zoo and for our visitors, huge efforts have been made by the entire zoo team to ensure all our animals continue to be well cared for.
"Significant help has been received from our colleagues in the Parks and Leisure Department and Property Maintenance who have also worked tirelessly to enable the zoo to reopen this Friday.
"We look forward to welcoming everyone back to the zoo."
On Friday, the zoo will have a full schedule of feeding times for visitors to enjoy, as well the unveiling of some new arrivals, four Tamworth piglets, who were born during the Easter weekend.