Adele's Rolling in the Deep hit and her smash-hit album 21 earned her four big prizes, including Top Alternative Song, Top Billboard 200 Album and Top Pop Album.
And she also picked up trophies for Top Hot 100 (singles) Artist and Billboard 200 (album) Artist.
LMFAO were the big winners at the ceremony, which Adele did not attend, claiming six awards - five for their 2011 smash-hit Party Rock Anthem and one for Top Duo or Group.
Other multiple winners included Coldplay who took home four awards, including Top Rock Album and Top Alternative Album for Mylo Xyloto.
But few music fans will be talking about who won what after a string of spectacular performances and showstopping tributes to 2012 Millennium Awards winner Whitney Houston, Donna Summer and late Beastie Boys rapper Adam Yauch.
LMFAO kicked off the show with a high-energy medley of their 2011/2012 hits Party Rock Anthem, Sorry For Party Rocking and Sexy & I Know It, but it was Cee Lo Green's and Goodie Mob's return to Las Vegas and Jordin Sparks and John Legend's tribute to Houston that stood out as highlights.
Sparks landed one of the night's many standing ovations after performing a pitch-perfect rendition of Whitney's I Will Always Love You and Cee Lo and his rap posse also brought the audience at the MGM Grand Garden Arena to its feet with their rousing rendition of the Beastie Boys Fight For Your Right (to Party).
Other performance highlights came from Katy Perry, Justin Bieber, Usher, Carrie Underwood, Linkin Park and Chris Brown, while 2012 Icon Award winner Stevie Wonder closed out the show by performing a medley of hits, like Higher Ground and Overjoyed with Alicia Keys.
The blind soul man, joked: "This is my time... and I'm looking good too", then asked for a birthday gift from his duet partner and insisted she sing her Jay-Z collaboration, Empire State of Mind, a Capella. Keys gladly obliged as Wonder sang: "You gave me my gift."
The singer then handed over the Icon Award to her personal icon, prompting the soul legend to drop his dark glasses and pretend to look at his trophy.
He said: "I can touch it and see it more than seeing it."
Wonder urged fans to "commit yourselves to using your heart and joining with me to putting your best love forward... and committing yourselves that if we come together and bring our hearts together for unity, we can change the world by being as one".
Aside from the stunning performances, there were award wins for Bieber, Perry, U2, Foster The People and Coldplay while Taylor Swift was named Billboard Woman of the Year and Lil' Wayne was crowned Top Male Artist.
The list of winners is:
Social Artist of the Year - Justin Bieber
Top Artist - Adele
Woman of the Year - Taylor Swift
Top Female Artist - Adele
Top Billboard 200 Artist - Adele
Top Hot 100 Artist - Adele
Top Digital Songs Artist - Adele
Top Radio Songs Artist - Adele
Top Streaming Artist - Rihanna
Top Digital Media Artist - Adele
Top Pop Artist - Adele
Top Country Artist - Lady Antebellum
Top Alternative Artist - Coldplay
Top Latin Artist - Shakira
Top Christian Artist - Casting Crowns
Best New Artist - Wiz Khalifa
Top Duo/Group - LMFAO
Top Male Artist - Lil Wayne
R&B Artist of the Year - Chris Brown
Top Rock Artist - Coldplay
Top Touring Act - U2
Top Dance Act - Lady Gaga
Top Billboard 200 Album - 21 by Adele
Top Pop Album - 21 by Adele
Top R&B Album - 4 by Beyonce
Top Rap Album - Tha Carter IV by Lil Wayne
Top Country Album - My Kinda Party by Jason Aldean
Top Rock Album - Mylo Xyloto by Coldplay
Top Alternative Album - Mylo Xyloto by Coldplay
Top Latin Album - Formula: Vol. 1 by Romeo Santos
Top Dance Album - Born This Way by Lady Gaga
Top Christian Album - Come To The Well by Counting Crowns
Hot 100 Song of the Year - Party Rock Anthem by LMFAO
Top Rock Song - Pumped Up Kicks by Foster The People
Top Digital Song - Party Rock Anthem by LMFAO
Top Radio Song - Give Me Everything by Pitbull Feat. Ne-Yo, Afrojack & Nayer
Top Streaming Song (Audio) - Rolling in The Deep by Adele
Top Streaming Song (Video) - Super Bass by Nicki Minaj
Top Pop Song - Party Rock Anthem by LMFAO
Top R&B Song - Motivation by Kelly Rowland & Lil Wayne
Top Rap Song - Party Rock Anthem by LMFAO
Top Country Song - Dirt Road Anthem by Jason Aldean
Top Alternative Song - Rolling in the Deep by Adele
Top Latin Song - Danza Kuduro by Don Omar & Lucenzo
Top Dance Song - Party Rock Anthem by LMFAO
Top Christian Song - Blessings by Laura Story
Icon Award - Stevie Wonder
Spotlight Award - Katy Perry
Millennium Award - Whitney Houston
Battle of The Bands Dreamseeker Artist of the Year - Patent Pending