Running from 2 - 9 August, the Festival - organised by the Apprentice Boys of Derry - will feature over 20 different events across the city, including live music, dance, living history, tours and exhibitions.
The Bluegrass and Folk Weekend will open the Festival on Saturday and will showcase the very best mix of modern and Americana folk bluegrass with 12 acts performing over three days
Elsewhere, over 40 of Northern Ireland's brightest new music stars take to the stage in a number of the city's cafes to play covers and originals from the worlds of jazz, blues, soul, rock and pop as part of the Culture Bite event.
The Maiden City Festival will also play host to the Ulster Highland Dance Championships, while a First World War exhibition - The Art of War - will showcase trench art incorporating original artefacts that were crafted by soldiers during WWI.
Festival Director, Jonathan Burgess, said: "This year promises another jam-packed Festival and we would encourage everyone to come into town and soak up the atmosphere.
"The city will truly come to life and we are hoping for the sun to shine on the town for the whole week.
"If the rain does make an appearance it won't dampen our spirits though!"